47 - Drugs causing Parkinsonism

Here is a list of drugs and toxins causing parkinsonism :

1. Fluoxetine
2. Valproate
3. Alpha methyl dopa
4. Neuroleptics
5. Dopamine depleting agents
6. Anti-emetics
7. Lithium carbonate
8. Some selective anti-psychotics

Toxins which cause parkinsonism are :

1. CO ( carbonmonoxide )
2. Cyanide
3. CS2
4. Manganese
5. Methanol
6. MPTP
7. N-Hexane

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52 - Drugs causing Fatty liver

1. Antiarrythmics - Amiodarone

2. Antibiotic - Tetracycline ( high-dose, intravenous )

3. Anticonvulsant - Valproic acid

4. Antiviral - Dideoxynucleosides ( eg: Zidovudine ), protease inhibitors ( indinavir, ritonavir )

5. Oncotherapeutics - Asparginase, Methotrexate .

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55 - Drugs causing Megaloblastic anemia

1. Phenytoin (anticonvulsant)

2. Primidone (anticonvulsant)

3. Phenobarbitone (anticonvulsant)

4. Sulfasalazine

5. Nitrous oxide
6. Folate antagonists (inhibitors of Dihydrofolate reductase) like Methotrexate, Pentamidine,     Pyrimethamine, Triamterene, Trimethoprim and Cotrimoxazole.
7. Drugs that inhibit DNA synthesis may cause Megaloblastic anemia
example : 6a. Purine antagonists = 6-Mercaptopurine, Azathioprine.
6b. Pyramidine antagonists = 5 FU, Cytosine arabinoside .

6c. Others = Hydroxyurea, acyclovir and zidovudine (AZT, Azidothymidine).
8. Nitrofurantoin (less well documented)
9. Tetracycline (less well documented)
10. Anti-Tuberculosis drugs (less well documented)

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65 - Drugs causing CYP3A inhibition

1. HIV antivirals : Indinavir, nelfinavir, ritonavir, Saquinavir
2. Clarithromycin
3. Itraconazole and Ketaconazole
4. Nefazodone
5. Telithromycin
6. Aprepitant
7. Erythromycin
8. Grapefruit juice
9. verapamil, diltiazem
10. Cimetidine
11. Amiodarone
12. Chloramphenicol
13. Ciprofloxacin
14. Delaviridine
15. Diethyl-dithiocarbamate
16. fluvoxamine
17. gestodene
18. Imatinib
19. Mibefradil
20. Mifepristone
21. Norfloxacin
22. Norfluoxetine
23. Starfruit
24. Voriconazole

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